The neuroprotective effects of naringenin (naringenin) are mainly reflected in the following aspects:
Improvement of cognitive ability: naringenin is able to protect nerve cells and improve cognitive ability by regulating inflammatory factors and oxidative stress. For example, in animal experiments, naringenin significantly improved the deterioration of neurological function due to cerebral ischemia-reperfusion injury in ovariectomized rats, and promoted nerve regeneration.
Inhibition of neuronal degeneration: Naringin has a significant inhibitory effect on the degeneration of dopaminergic neurons, which helps to slow down the development of neurodegenerative diseases.
Antioxidant and anti-inflammatory: Naringin protects nerve cells from damage by scavenging free radicals and inhibiting oxidative stress and inflammatory responses. Studies have shown that naringin can modulate the activity of antioxidant enzymes in the body and reduce the level of oxidative stress, thus reducing nerve cell damage.
Promote nerve regeneration: Naringin can up-regulate the expression of nerve regeneration-related proteins, such as calbindin, α/β-tubulin and Neu-N, and promote the survival and regeneration of neurons. For example, naringenin significantly increased the levels of these proteins in the hippocampus and prefrontal cortex and improved neurological function in a cerebral ischemia-reperfusion model in ovariectomized rats.
Protection of neural network integrity: Naringin helps prevent the onset and progression of neurodegenerative diseases by protecting mature neurons labeled with neuronal nuclear antigen (Neu-N) and maintaining the integrity of neural networks.